Lynch syndrome kuj tseem hu ua hereditary nonpolyposis colorectal cancer (HNPCC). Nws yog qhov xwm txheej uas tau ua rau muaj kev pheej hmoo ntawm txoj hnyuv loj thiab lwm yam mob qog noj ntshav, thiab nws ua rau muaj kev pheej hmoo tias cov qog nqaij hlav no tshwm sim thaum muaj hnub nyoog yau dua li ib txwm - yau dua 50 xyoo. Yog tias koj ntseeg tias koj yuav muaj kev pheej hmoo, kawm paub tias Lynch syndrome tau kuaj mob li cas.
Cov kauj ruam
Txoj Kev 1 ntawm 3: Paub Txog Koj Txoj Kev pheej hmoo ntawm Lynch Syndrome
Kauj Ruam 1. Txiav txim siab yog tias koj muaj keeb kwm tsev neeg mob qog noj ntshav lossis mob qog noj ntshav
Ib ntawm cov tsos mob tseem ceeb rau Lynch syndrome yog tsev neeg keeb kwm ntawm txoj hnyuv thiab mob qog noj ntshav, tshwj xeeb yog thaum tseem hluas.
- Yog tias koj nyuam qhuav tau kuaj pom tias muaj mob qog noj ntshav koj yuav muaj tus mob Lynch syndrome, tshwj xeeb tshaj yog tias koj muaj hnub nyoog qis dua 50 xyoos.
- Yog tias koj muaj kev noj qab haus huv thiab hluas, tab sis ntau dua ib tus neeg hauv tsev neeg tam sim no tau lees paub mob qog noj ntshav thaum muaj hnub nyoog 50 lossis qis dua, koj tuaj yeem nqa cov noob rau Lynch syndrome uas ua rau koj muaj kev pheej hmoo siab dua, thiab koj yuav tsum mus ntsib kws kho mob rau kev tshuaj ntsuam caj ces. Qhov no tuaj yeem pab txheeb xyuas yog tias koj yuav tsum pib tshuaj xyuas nrog txoj hnyuv loj thaum muaj hnub nyoog yau dua li ib txwm pom zoo.
Kauj Ruam 2. Saib xyuas cov tsos mob ntawm txoj hnyuv loj
Lynch syndrome yog kev hloov pauv caj ces uas ua rau muaj kev pheej hmoo nce ntxiv ntawm txoj hnyuv thiab mob qog noj ntshav - Lynch syndrome nws tus kheej tsis muaj tsos mob tshwm sim. Tib txoj hauv kev los kuaj mob Lynch syndrome yog kuaj koj tus kws kho mob. Yog tias koj ntseeg tias koj yuav muaj kev pheej hmoo vim yog tsev neeg muaj keeb kwm mob qog noj ntshav lossis mob qog noj ntshav hauv tsev, koj yuav tsum tau ceev faj txog cov tsos mob ntawm tus mob kheesxaws hnyuv, txawm tias thaum tseem hluas.
- Saib xyuas cov kev hloov pauv hauv plab. Kev hloov pauv hauv tus cwj pwm quav yuav kav ntev dua ob peb hnub. Cov kev hloov pauv no tuaj yeem yog raws plab, cem quav, quav me dua lossis quav quav, thiab qhov kev xav tias koj yuav tsum muaj lub plab zom mov tom qab nyuam qhuav dhau mus.
- Saib ntshav hauv cov quav. Lwm cov tsos mob ntawm tus mob kheesxaws yog cov ntshav hauv koj lub plab. Qhov no suav nrog tso ntshav los ntshav los ntawm cov quav. Koj tuaj yeem pom cov ntshav liab lossis cov quav yuav zoo li tsaus ntuj thiab nyob tsis tswm.
- Saib xyuas rau lwm qhov kev hloov pauv ntawm lub cev. Lynch syndrome txuas nrog txoj hnyuv lossis lwm yam qog nqaij hlav tuaj yeem ua rau qaug zog thiab qaug zog hauv ib tus neeg uas muaj nws. Ib tus neeg kuj tseem tuaj yeem ua rau poob phaus yam tsis xav tau lossis tsis piav qhia. Koj kuj tseem yuav mob plab lossis mob plab.
Txoj Kev 2 ntawm 3: Txheeb Xyuas Lynch Syndrome
Kauj Ruam 1. Mus ntsib koj tus kws kho mob
Yog tias koj xav tias koj yuav muaj kev pheej hmoo rau tus mob Lynch syndrome, koj yuav tsum mus ntsib koj tus kws kho mob, uas feem ntau yuav xa koj mus ntsib kws kho mob tshwj xeeb hauv noob caj noob ces hu ua Medical Geneticist. Lawv yog cov kws tshaj lij hauv kev muab kev tshuaj ntsuam caj ces, kev tawm tswv yim, thiab kev tswj hwm kab mob caj ces zoo li lynch syndrome.
Koj yuav tsum mus ntsib koj tus kws kho mob yog tias koj muaj ib qho ntawm cov tsos mob ntawm lub cev, lossis muaj keeb kwm tsev neeg ntawm txoj hnyuv lossis lwm yam mob qog noj ntshav
Kauj Ruam 2. Txiav txim siab yog tias koj muaj caj ces predisposed
Lynch syndrome tuaj yeem xav tias yog tsev neeg keeb kwm ntawm txoj hnyuv, endometrial, thiab lwm yam qog nqaij hlav, tshwj xeeb tshaj yog tias cov qog nqaij hlav tau tshwm sim hauv cov neeg hauv tsev neeg yau. Kev kuaj mob yog txiav txim siab los ntawm kev kuaj caj ces.
- Koj tus kws kho mob kuj tseem tuaj yeem nug txog cov txheeb ze nrog cov qog nqaij hlav hauv lub plab, hnyuv me, lub paj hlwb, lub raum, lub siab, lossis zes qe menyuam, vim tias cov noob uas tau hloov pauv hauv Lynch syndrome ua rau muaj kev pheej hmoo ntau tus mob qog noj ntshav sib txawv.
- Koj tus kws kho mob yuav nug txog mob qog noj ntshav hauv ib tiam dhau los, tshwj xeeb tshaj yog tias koj muaj cov neeg mob qog noj ntshav ntau xyoo hauv koj tsev neeg.
Kauj Ruam 3. Tau kuaj qog
Yog tias koj lossis ib tus neeg hauv tsev neeg muaj qog, tus kws kho mob tuaj yeem kuaj lub qog seb koj puas muaj tus mob Lynch syndrome. Nws tuaj yeem txiav txim siab yog tias qee cov protein nyob hauv cov qog uas qhia txog Lynch syndrome.
- Yog tias cov qog kuaj pom zoo, koj yuav tsis muaj Lynch Syndrome. Kev hloov pauv tuaj yeem tsim tsuas yog hauv cov qog lossis cov qog nqaij hlav cancer. Tom qab qhov ua tau zoo, koj tus kws kho mob tuaj yeem ua qhov kev tshuaj ntsuam caj ces txhawm rau txiav txim siab tias koj puas muaj Lynch Syndrome.
- Yog tias ib tus neeg hauv koj tsev neeg tau mob qog noj ntshav ob peb xyoos dhau los, tsev kho mob tseem yuav muaj cov nqaij mos uas koj tus kws kho mob tuaj yeem kuaj.
Kauj Ruam 4. Tau txais kev kuaj mob caj ces
Tam sim no muaj cov kev sim muaj rau ntau tus kev hloov pauv uas tshwm sim hauv Lynch syndrome. Cov kev ntsuas no tshuaj ntsuam rau kev hloov pauv hauv MLH1, MSH2, MSH6, thiab EPCAM noob.
Koj tuaj yeem xa koj tus kws kho mob xa koj cov ntshav mus kuaj, tab sis koj tseem tuaj yeem kuaj koj cov ntshav los ntawm ntau qhov kev sim sib txawv. Yog tias koj txaus siab rau kev sim sab nrauv, txheeb xyuas Myriad myRisk, Quest Diagnostics, thiab Invitae
Txoj Kev 3 ntawm 3: Nkag Siab Lynch Syndrome
Kauj Ruam 1. Paub tias Lynch syndrome yog kab mob keeb kwm
Lynch syndrome yog ib yam mob. Kev ua yuam kev caj ces uas muaj nyob hauv cov neeg uas muaj tus kab mob Lynch yog pab pawg ntawm cov noob uas ua rau cov protein uas tau pab kho cov noob.
- Cov noob ntawm pab pawg no yog rau "kev kho tsis sib xws ntawm cov noob," uas yog cov noob uas kho qhov ua yuam kev feem ntau thaum DNA rov tsim nws tus kheej. Kev ua yuam kev hauv cov txheej txheem sib txuam no tuaj yeem kho tau ib txwm, tab sis hauv Lynch Syndrome, lawv tsis tuaj yeem kho dua vim tias cov noob uas cim rau cov protein uas ua kho yog lawv tus kheej puas.
- Qhov ua rau mob qog noj ntshav cuam tshuam nrog Lynch syndrome ntseeg tau tias yog kev txuam nrog ntawm cov kev hloov pauv no hauv DNA.
- Yog tias leej niam lossis leej txiv muaj daim ntawv theej tawm ntawm ob ntawm cov noob no, muaj 50% txoj hauv kev uas nws tau xa mus rau lawv tus menyuam.
Kauj Ruam 2. Nkag siab tias qhov zoo rau Lynch syndrome txhais li cas
Yog tias koj qhov kev sim tshuaj ntsuam pom zoo rau Lynch syndrome, nws txhais tau tias koj txoj kev pheej hmoo mob qog noj ntshav yog nyob nruab nrab ntawm 60 txog 80%. Nws tsis txhais tau tias koj yuav muaj tus mob qog noj ntshav lossis mob qog noj ntshav, tab sis kev pheej hmoo ntawm txoj hnyuv loj thiab mob qog noj ntshav nrog rau lwm cov qog nqaij hlav tau nce.
- Txoj sia pheej hmoo ntawm kev mob qog noj ntshav endometrial tuaj yeem yog 20 txog 60%.
- Txoj kev pheej hmoo hauv lub neej ntawm lwm cov qog nqaij hlav tau nce tsawg dua 20%.
Kauj Ruam 3. Mus ntsib koj tus kws kho mob rau txoj haujlwm tiv thaiv kab mob qog noj ntshav
Lynch syndrome tsis kho tau. Yog tias koj qhov kev tshuaj ntsuam caj ces zoo, qhov no txhais tau tias koj yuav tsum tau sab laj nrog kws tshuaj sab laj nrog rau koj tus kws kho mob txhawm rau txiav txim siab koj txoj kev ua tau zoo tshaj plaws rau kev tiv thaiv qog noj ntshav thiab tshuaj xyuas yav tom ntej.
