Benzocaine yog tshuaj loog hauv zos feem ntau siv los kho qhov mob. Kev npaj Benzocaine feem ntau ua tiav hauv tsev kawm ntawv chaw teeb tsa los ua kom pom cov kua qaub-catalyzed esterification ntawm carboxylic acid nrog cawv, hu ua Fischer esterification.
Cov kauj ruam
Kauj Ruam 1. Ntxiv cov hlau nplaum sib xyaw ua ke, 1.0g ntawm p-aminobenzoic acid, thiab 10mL ntawm ethanol meej rau hauv qab puag ncig lub raj mis
Kauj Ruam 2. Swirl qhov sib tov kom txog thaum cov khoom tau yaj tag
Kauj Ruam 3. Ntxiv 1mL ntawm cov kua tshuaj sulfuric acid nrog cov tshuaj Pasteur rau hauv cov tshuaj ethanol-aminobenzoic
Ib qho khoom yuav ua kom tawm ntawm qhov kev daws teeb meem. Nco ntsoov, sulfuric acid yog xeb heev thiab tuaj yeem ua rau muaj tshuaj lom hnyav yog tias tso cai los ua rau koj cov tawv nqaij. Siv kev ceev faj heev thaum tuav cov tshuaj no.
Kauj Ruam 4. Txuas lub condenser mus rau lub thoob hauv qab uas muaj cov tshuaj ethanol, thiab teeb tsa lub cuab yeej rau cua sov hauv qab dej ntws
Cov dej-hauv lub raj txuas rau hauv qab ntawm tus kais dej thiab lub raj xa dej tawm txuas mus rau sab saum toj ntawm tus kais dej.
Kauj Ruam 5. Ua kom sov cov tshuaj rau ntawm cov phaj kub hauv qab maj mam rov ua dua li kwv yees li 30 feeb
Teem lub cua sov rau 2 thawj zaug thiab sib tov rau 6-7. Tej zaum koj yuav tsum tau kho lub cua sov kom ua kom cov kua rov qab los, tab sis tsis kub hnyiab. Koj paub qhov kev daws teeb meem yog rov ua kua thaum cov kua ua kua rau ntawm qhov taub ntawm lub condenser qhov twg lub condenser txuas nrog rau hauv qab puag ncig lub raj mis.
Kauj Ruam 6. Yog tias muaj cov nag lossis daus tseem nyob tom qab cua sov, tshem lub condenser tawm ntawm cov raj hauv qab thiab tshem cov raj hauv qab los ntawm cov phaj kub
Txias cov tshuaj hauv chav sov li 2-3 feeb.
Kauj Ruam 7. Ntxiv 3mL ntawm cov cawv ethanol thiab 0.5mL ntawm sulfuric acid (los ntawm qhov poob) mus rau lub thoob hauv qab lub raj mis uas muaj cov tshuaj tov thiab nag lossis daus
Rov txuas lub condenser mus rau lub thoob hauv qab lub raj mis, thiab rov ua kom sov dua nyob rau hauv maj mam rov ua dua kom txog thaum tag nrho cov khoom tau yaj. Nws yog ib qho tseem ceeb heev rau qhov kev sim no kom ua tiav uas TXHUA cov khib nyiab yaj thaum lub sijhawm no.
Kauj Ruam 8. Thaum cov khoom tau yaj tag, txuas ntxiv cov cua sov hauv qab maj mam rov qab mus rau lwm 30 feeb
Kauj Ruam 9. Tshem lub raj hauv qab puag ncig los ntawm cov cua sov thiab tso cov tshuaj sib tov kom txias rau chav sov
Qhov no yuav tsum siv sijhawm li 7-10 feeb.
Kauj Ruam 10. Sau 100mL beaker nrog 30mL dej thiab ncuav cov dej txias ua kom sib tov rau hauv lub beaker uas muaj 30mL dej
Kauj Ruam 11. Txheeb xyuas cov tshuaj sib xyaw ua ke thiab dej daws rau pH ntawm txog 8
Txhawm rau ua qhov no, xam kwv yees kwv yees li ntawm 10% aqueous sodium carbonate uas yuav tsum tau ua kom nruab nrab tag nrho cov tshuaj sulfuric acid uas koj siv (Feem ntau ntawm 18-24 mL).
Kauj Ruam 12. Maj mam ncuav cov nyiaj suav ntawm 10% aqueous sodium carbonate rau hauv lub beaker uas muaj cov tshuaj sib tov thiab dej tov
Nco ntsoov ntxiv cov sodium carbonate maj mam li frothing tshwm sim thaum nruab nrab. Ib qho khoom yuav tsum tau nag. Qhov no yog nyoos benzocaine.
Kauj Ruam 13. Sib sau koj lub tshuab nqus tsev thiab sau cov roj benzocaine los ntawm lub tshuab nqus tsev pom
Kauj Ruam 14. Nyuaj cov benzocaine nyoos uas tau sau thaum lub tshuab nqus tsev
Kauj Ruam 15. Hloov cov benzocaine nyoos mus rau 50mL Erlenmeyer hwj thiab ntxiv cov sib nqus sib tov thiab 20mL dej
Kauj Ruam 16. Muab lub hwj Erlenmeyer tso rau ntawm lub phaj kub thiab teeb lub cua sov rau 2-3 thiab sib tov rau 6-7
Ua kom sov cov benzocaine-dej sib xyaw kom txog 60 ° C (140 ° F). Koj tuaj yeem ntsuas qhov ntsuas kub los ntawm kev tso tus pas ntsuas kub tso rau sab saum toj ntawm lub condenser thiab zawv zawg tus pas ntsuas kub los ntawm lub rhaub dej kom txog thaum tus pas ntsuas kub lub taub hau so 1 txog 2 centimeters (0.4 txog 0.8 hauv) saum cov kua hauv qab puag ncig lub raj mis.
Kauj Ruam 17. Ntxiv cov methanol txaus rau cov dej rhaub kom yaj cov benzocaine khoom
Cov kauj ruam no tsuas yog xav tau 5-10mL ntawm methanol. Tsis txhob ntxiv cov tshuaj methanol ntau dua li qhov tsim nyog kom yaj cov khoom.
Kauj Ruam 18. Tshem Erlenmeyer lub hwj los ntawm cov cua sov ib zaug thaum tag nrho cov khoom tau yaj, thiab tso cov tshuaj kom txias rau chav sov
Qhov no yuav tsum siv 7-10 feeb.
Kauj Ruam 19. Txias cov tshuaj tov hauv cov dej khov nab kuab rau 15 feeb kom ua tiav cov benzocaine crystallization
Kauj Ruam 20. Siv lub tshuab nqus tsev kom cais cov benzocaine crystallized
Kauj Ruam 21. Ntsuas qhov khoom kawg thiab suav qhov feem pua tawm los
